Lan Guo

Lan Guo
  • Assistant Research Professor

Contact Info

Malott Hall, room 3062


Dr. Lan Guo's focus is on deciphering the pathogenesis of Alzheimer’s disease, She is trying to probe the role of neuronal-microglial crosstalk in the development of neurodegeneration in this devastating disorder by adopting multidisciplinary approaches including molecular neurobiology, live cell imaging and transcriptomics. The understanding of key mechanisms of such complicated inter-cell type communication holds hope for the development of therapeutic avenues for the treatment of Alzheimer’s disease.

Selected Publications

Chen H, Tian J, Guo L, Du H. Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination. Sci Rep. 2020 Oct 16;10(1):17589. doi: 10.1038/s41598-020-74613-9. PMID: 33067541; PMCID: PMC7568535.

Yuan X, Wang L, Tendon N, Sun H, Tian J, Du H, Pascual JM, Guo L. Triheptanoin Mitigates Brain ATP Depletion and Mitochondrial Dysfunction in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2020 Sep 25;. doi: 10.3233/JAD-200594. [Epub ahead of print] PubMed PMID: 33016909.

Guo L, Tian J, Du H. Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer's Disease. J Alzheimers Dis. 2017;57(4):1071-1086. doi: 10.3233/JAD-160702. PMID: 27662318; PMCID: PMC5605817.