Identify mechanisms of repair of nitrated SERCA2a in myocytes following its modification by acute and chronic exposure to peroxynitrite.
Compare the identity of myocyte proteins nitrated by chronic PN exposure by SIN-1 and by inflammatory cytokines with those of aging skeletal muscle.
Identify cellular mechanisms of repair of PN-induced oxidative modifications of cysteines and methionines, in SERCA2a in relationship with those of the total cellular proteome.
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