Characterize the complex between Bcl-2 and SERCA and the effect of aging and Bcl-2 phosphorylation on complex formation.
Characterize the effects of the pro-apototic proteins Bak and Bad on the SERCA/Bcl-2 interaction.
Analyze the functional and subproteomic stoichiometry of the composition of important SERCA/protein complexes affected by Bcl-2 and those affecting the interaction of SERCA with Bcl-2.
Measure the functional interaction of Bcl-2 with SERCA in vivo and conduct proteomic analyses of the SERCA/Bcl-2 protein complexes.
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