Use global proteomics (The Biological Systems Analysis & Mass Spectrometry group at PNNL) to identify proteins and modified proteins involved in oxidation, repair, and signaling pathways from projects.
Use proteomics-based detection strategies to identify proteins isolated from “targeted” fraction preparations and focus on the identification of post-translational modifications in the proteomes being studied or in target proteins (The Applied Proteomics Laboratory group at the University of Kansas).
Use microdialysis and microseparation methods (Analytical Component of the Core) for near real time measurements of the release of amino acid neurotransmitters and nitric oxide metabolites both in mouse brain and cell culture systems
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