HBC June-July 2019 News Bulletin

Wednesday, July 31, 2019

 

HBC Interim Director

John StobaughBill Picking stepped down from his position as director of the Higuchi Biosciences Center (HBC) at the end of June 2019 to focus on his research and teaching commitment.  As of July 1st, John Stobaugh assumed the role of interim director of HBC.  He is a professor of pharmaceutical chemistry and associate dean of research & graduate affairs in the School of Pharmacy.  He also serves as associate director of academic research at the HBC.

We would like to take this opportunity to thank Bill Picking for his service as director of the HBC for these past five years.

 

O’Leary Shared Service Center Satellite Office

This is a reminder that on July 17, 2019 the O’Leary Shared Service Center began to hold office hours in KU’s West District to facilitate in-person meetings for PI’s located in the district.  The satellite office is located in McCollum Laboratories, Room 129.  It is open the 1st and 3rd Wednesday of the month from 1 to 4 pm. 

 

Upcoming Fall Symposium

GRASP logoThe An HBC sponsored symposium is scheduled for this coming fall.   The 2019 Great Plains Regional Annual Symposium on Protein and Biomolecular NMR (GRASP NMR), a regional symposium on macromolecular NMR applications and techniques, will be held at the KU School of Pharmacy building on November 22 -23, 2019.  Registration is currently open and early-bird registration fees will be available until September 10, 2019.           

 

J.R. & Inez Jay Fund Research Awards   

Adam SmithMark Farrell

Two projects were selected this year to receive the 2019 J.R. and Inez Jay Fund research award at the University of Kansas. The first proposal selected, titled “Sugar coated vaccines for the treatment of opioid use disorder,” was submitted by Mark Farrell, assistant professor of medicinal chemistry, and Adam Smith, assistant professor of pharmacology and toxicology. The project will investigate a new approach to opioid conjugate vaccines.

Mark RichterThe second project selected was submitted by Mark Richter, professor of molecular biosciences.   The project, titled “Continuous monitoring of histamine in the brain,” will be conducted in collaboration with Candan Tamerler, professor of mechanical engineering, Paul Hanson, professor of chemistry, and George Wilson, distinguished professor emeritus of chemistry.   The proposal addresses the need for real-time continuous measurement of histamine levels in the brain and in other tissues as a biomarker and pre-indicator of multiple immunological, neurological, and cardiovascular disorders.

 

KU NIH Center of Biomedical Research Excellence (CoBRE) in Chemical Biology of Infectious Disease (CBID) Pilot Projects awards

The KU NIH CoBRE in Chemical Biology of Infectious Disease (CBID) received sixteen innovative and well qualified Pilot Project applications in February.  Out of the six selected proposals (four potential awards and two alternates) sent to NIH, four projects were approved.  They are:

  • Dr. Brian Ackley – University of Kansas, “On again, off again: Is pH a critical factor in pathogen killing?”
  • Dr. Josie Chandler – University of Kansas, “Chemical biology studies of malleilactone, a small-molecule toxin produced by Burkholderia pseudomallei”
  • Dr. Philip Hardwidge – Kansas State University, “Bacterial glycosyltransferase inhibitors as anti-virulence compounds”
  • Dr. Wolfram Zückert – University of Kansas Medical Center, “Small molecule inhibitors of bacterial surface lipoprotein secretion”

Congratulations to all.



Grant Submission Deadlines

March 5, 2021
NIH standard deadline for Research Grants and Cooperative Agreements (R01 and U01) – renewal, resubmission, revision.

March 11, 2021
DoD Breast Cancer Breakthrough Award Levels 1 & 2 & Era of Hope Scholar Award – Pre-application.

March 12, 2021
DoD Breast Cancer Breakthrough Award Levels 3 & 4  & Innovator Award – Pre-application.

March 16, 2021
NIH standard deadline for Other Research Grants and Cooperative Agreements (R03, R21, R33, R21/R33, R34, R36, UH2, UH3, UH2/UH3) – renewal, resubmission, revision.

Recent Awards

Yoshiaki Azuma, Professor, Department of Molecular Biosciences, was awarded $35,000 by the University of Kansas Medical Center Research Institute for his project entitled “Targeting mitotic function of the PICH (Polo-like kinase interacting checkpoint helicase) for novel therapeutics of TNBC.”

Heng Du, Associate Professor, Department of Pharmacology & Toxicology, transferred a grant from  the University of Dallas, Texas.  It is a BrightFocus Foundation project entitled “Synaptic mitochondrial calcium uniporter deregulation and synaptic injury in Alzheimer's disease.”

Teruna Siahaan, Aya and Takeru Higuchi Distinguished Professor and Associate Chair, Department of Pharmaceutical Chemistry, was awarded $25,000 by the PHRMA Foundation as mentor for Kelly Schwinghamer for the project entitled “Non-Invasive Brain Delivery Clearance  and Efficacy of Therapeutic Antibodies in Mice.”

Liang Xu, Professor, Department of Molecular Biosciences, was awarded $35,000 by the University of Kansas Medical Center Research Institute for his project entitled “Drug the Undruggable Musashi Oncoprotein by Fragment-based Drug Discovery.”

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