HBC Scientists’ Conference Presentations

HBC scientists gave presentations at the North American Bioanalytical Forum, the annual meeting of the American Association of Pharmaceutical Scientists and the Society for Neuroscience 30th Annual Meeting.

North American Bioanalytical Forum, Kansas City, MO, September 17-20, 2000
Kansas City, Missouri

Miniaturized Electrochemical Systems for Bioanalysis, S.M. Lunte, R.S. Martin, A.J. Gawron, N.A. Lacher and S.A. Pasas.

Analysis of Small Volume Biological Samples by Capillary Electophoresis, C.E. Lunte, (Oral).

Bioanalysis of DFMO by Coupled-Column LC or by Capillary Electrophoresis with LIF Detection—A Comparison, J.F. Stobaugh, R.G. Carlson, M.F. Kilkenny and C. Ampasavate, (Oral).

Separation and Detection of Angiotensin Copper-Peptide Complexes using Capillary Electrophoresis with UV and Electrochemical Detection, N.A. Lacher, A.J. Gawron and S.M. Lunte.

Use of Microdialysis Sampling to Investigate the Metabolism of Substance P in the Brain by Capillary Electrophoresis with Laser-Induced Fluorescence Detection, A.L. Freed, J.D. Cooper, M.I. Davies and S.M. Lunte.

Poly(dimethylsiloxane)-Based Microchip CE Devices Utilizing Electrochemical Detection with Carbon Electrodes, R.S. Martin, A.J. Gawron and S.M. Lunte.

Evaluation of Two Column Packing Techniques for Capillary Electrochromatography, C. Pham, M. Yang and J.F. Stobaugh.

Pharmaceutical/Biopharmaceutical Applications of CEC, P.D.A. Angus, C.W. Demarest, T. Catalano and J.F. Stobaugh.

Target Specific Preparation from Aqueous Media with Molecular Imprinted Polymers, S.E. Moring, O.S. Wong and J.F. Stobaugh.

High Performance Liquid Chromatographic Method for the Determination of Homocysteine in Human Plasma Using a Water-Soluble Phosphine Reducing Agent and Fluorogenic Derivatization, M.J. Whittle, J.F. Stobaugh, and O.S. Wong.

Correlation of the Capacity Factor in Vesicular Electrokinetic Chromatography with the Octanol: Water Partition Coefficient for Charged and Neutral Analytes, J.L. Razak, B.J. Cutak, C.K. Larive and C.E. Lunte.

American Association of Pharmaceutical Scientists Annual Meeting and Exposition Indianapolis, IN October 29-November 2, 2000

Analytical Aspects of Microdialysis Sampling for Studying Peptide Drug Transport and Metabolism, S. M. Lunte, A. L. Freed, A. J. Gawron, J. D. Cooper, R. S. Martin, K. M. Heppert and M. I. Davies.

A Process for Continuous Production and Harvesting of Drug Particles using Super-critical Carbon Dioxide as an Antisolvent, B. Subramaniam, F. Niu, R. A. Rajewski.

Evaluation of the Intestinal Mucosal Permeation of an Opioid Peptide and Its Cyclic Prodrugs Using an In Situ Perfused Rat Ileum Model, W. Chen, J. Z. Yang, A. Bak, R. T. Borchardt.

Peptide Deamidation in Polymer Matrices, E. M. Topp.

Effect of Viscosity on the Deamidation Rate of Asn-hexapeptide, R. Li, M. J. Hageman, R. L. Schowen, R. T. Borchardt and E. M. Topp.

Studies of EC-domains Interactions in Forming Cell-to-Cell Adhesion in Caco-2 Cells, A. Ikesue, I. T. Makagiansar, T. J. Siahaan.

Inhibition Mechanism of T-lymphocyte Adhesion to Epithelial Cells via ICAM-1/LFA-1 Interactions, H. Yusuf-Makagiansar, I. T. Makagiansar, T. J. Siahaan.

Utilization of a LFA-1 Cyclic Peptide to Target Up-regulated Cellular ICAM-1: Mechanism of Binding and Internalization, H. Yusuf-Makagiansar, I. T. Makagiansar and T.J. Siahaan.

Micronization of Insulin from Organic Solution Using Supercritical Carbon Dioxide as Antisolvent, W. K. Snavely, B. Subramaniam, R. A. Rajewski and M. R. Defelippis.

Characterization of Steroidal Modulation of P-glycoprotein (Pgp) in the Human Sub-bronchial Epithelial Cell Line, Calu-3, K. O. Hamilton, G. Backstrom, M. Yazdanian and K. L. Audus.

Correlation of the Capacity Factor in Vesicular Electrokinetic Chromatography and the Octanol/Water Partition Coefficient for Charged and Neutral Analytes, J. L. Razak, B. J. Cutak, C. K. Larive and C. E. Lunte.

Usage of Novel Cyclodextrins as Solubilizing Agent in Parenteral Formulations: Regulatory Status, V. J. Stella.

The Use of Capillary Electrophoresis with Laser-Induced Fluorescence for the Determination of the Metabolism and Transport of Substance P at the Blood-Brain Barrier, A. L. Freed, J. D. Cooper, M. I. Davies, K. L. Audus and S. M. Lunte.

Transport Of Taxol And Its Analogs Across Bovine Brain Microvessel Endothelial Cell Monolayers, An In Vitro Model for Blood-brain Barrier, A. Keshavarz-Shokri, D. Dutta, Y. Liu, G. Georg and K. L. Audus.

Production of E-cadherin-Derived EC1 and EC1-EC2 Domains to Study the Mechanism of E-cadherin-E-cadherin Interaction, I. T. Makagiansar, P. Nguyen, A. Ikesue and T. J. Siahaan.

Comparison of Binding and Internalization Mechanisms of ICAM-1 derived Cyclic Peptides: cIBL and cIBC, M. E. Anderson, H. Yusuf-Makagiansar and T. J. Siahaan.

A Rigid Cyclic Prodrug of RGD-Pepti-domimetic: Synthesis and Antithrombic Activity, X. Song, C. R. Xu and T. J. Siahaan.

Cyclic Prodrugs of RGD Peptidomimetic with Various Macrocyclic Ring Sizes I: Synthesis and Antithrombic Activity, C. R. Xu, X. Song, T. J. Siahaan.

Experimental and Physiological Factors Influencing Microdialysis Sampling of Cerebral Glucose Concentrations: A Numerical Simulation, J. D. Reinert, M. Z. Southard and G. S. Wilson.

Cyclic Prodrugs of RGD Peptidomimetic with Various Macrocyclic Ring Sizes II: Kinetics and Mechanism of Degradation in Buffer and Biological Media, C. R. Xu, X. Song and T. J. Siahaan.

Cyclic prodrugs of RGD Peptidomimetic with Various Macrocyclic Ring Sizes. III: The Effect of Physicochemical Properties on Permeation through Cell Membranes, C. R. Xu, E. D. Hugger, X. Song, R. T. Borchardt and T. J. Siahaan.

The Effect of (SBE)7m-b-CD and HP-b-CD on the Stability and Solubilty of NSC-281612, An Experimental Anti-Neoplastic Agent, M. Jumaa and V. Stella.

Benzodiazepines in Lipid Emulsion Formulation: Effect of Autoclaving on Stability, M. Jumaa and B. W. Mueller.

Calorimetric Analysis of the Interaction between Cationic Lipids and Plasmid DNA using Isothermal Titration Calorimetry, B. A. Lobo, C. R. Middaugh.

Development of an Assay for Deamidation in a Type I’ Beta Hairpin Peptide, C. E. Stotz, Y. Song, E. M. Topp, R. T. Borchardt and R. L. Schowen.

Proteoglycans in Cationic Lipid-Mediated Gene Delivery, C. M. Wiethoff and C. R. Middaugh.

Mechanistic Interpretation of pH Effect on Asparagine Deamidation in Polymeric Formulation, Y. Song, M. Houchin, R. Schowen, R. Borchardt and E. Topp.

Reaction of Polyvinylpyrrolidone with Asn-hexapeptide (VYPNGA) During Stability Studies, A. J. M. D‘Souza, R. L. Schowen, R. T. Borchardt and E. M. Topp.

Society for Neuroscience 30th Annual Meeting, New Orleans, November 4-9, 2000

Definition of Ion Currents Through NMDA Receptors and an NMDA Receptor-like Complex: Effects of Ethanol. R. MacKinnon, A. Al Yahya, R. Pal, K. N. Kumar, and E. K. Michaelis. Departments of Pharmacology and Toxicology and Molecular Bioscience, Center for Neurobiology and Immunological Research, University of Kansas.

Cloning of Mouse Genomic DNA for Glutamate Pyruvate Transaminase (GPT) and Analysis of Genomic DNA From Hot/Cold and Fast/Slow Mice. X. Bao, D. Hui, T. Phillips, D. Ruden, M. Michaelis, and E. Michaelis, Departments of Pharmacology and Toxicology and Molecular Biosciences, University of Kansas, and Vet. Affairs, Oregon Health Science Center.

Glutamate Synthesizing Enzymes in Synaptosomes and Sensitivity to Ethanol (EtOH) in Mice. M. L. Michaelis, A. Benremouga, G. Wan, T. Zarcone, E. Vorontsova, S. Fowler, T. Phillips, D. Ruden, and E. K. Michaelis. Departments of Pharmacology and Toxicology, Molecular Biosciences and Human Development, University of Kansas and Vet. Affairs, Oregon Health Science Center.

Differential Expression of NR1 Splice Variant Forms in Dendrites of Hippocampal and Cerebellar Neurons Is Determined by mRNA Sorting. R. Pal, C. Leary, J. Hunt, M. Bechtel, K. N. Kumar, M. L. Michaelis, and E. K. Michaelis. Departments of Pharmacology and Toxicology, Center Mentally Ret. Res., Center for Neurobiology and Immunological Research, University of Kansas.