HBC affiliates made presentations at the AAPS meeting November 10-14, 2002, in Toronto.
Case for
Pro-Drugs, Valentino Stella
Effects
of Secondary Structure and Physical State in Peptide Deamidation, Richard
Schowen, Bei Li, David Vander Velde, Ronald Borchardt and Elizabeth Topp.
Epimerization of Asparagine
Residues in Model Peptides, Ronald Borchardt, Richard Schowen, David Vander
Velde, Bei Li, and Elizabeth Topp.
Synthesis and Deamidation of
Model Beta-Turn Peptides in the Solution and Solid State, Qiang Yu, Ronald
Borchardt, Elizabeth Topp, S. Lynn Winslow, and Teruna Siahaan.
Effect of PLGA Film Incorporation
on Peptide Deamidation, M. Louise Houchin, Ronald Borchardt, and Elizabeth
Topp.
Glutathione disulfide photolytic
degradation produces an aldehyde, Christian Schoeneich, Jiangning Ji,
Elizabeth Topp, and Ronald Borchardt.
Design, structural and biological
activities of peptides with linker for T-cell adhesion inhibition, S.D.S.
Jois, Teruna Siahaan, A. Maria Calcagno, M. Anderson, and T.C. Peng.
Design of beta-Turn Peptides
from CD2 as Therapeutic Agents t or Autoimmune Diseases, S.D.S. Jois. J. Liu,
Teruna Siahaan, and H. Y Makagiansar.
ICAM-1 peptide-MTX conjugate
targets drug delivery to activated T-cells in a collagen-induced arthritis
murine model Roger Rajewski, Tatyana Yakovleva, Michelle Mclntosh, A. Ikesue,
D.M. Pinson, and Teruna Siahaan.
Characterization of MTX-peptide
activity and selectivity compared to MTX, M. Anderson and Teruna Siahaan.
Investigation of Substance P Metabolism In Vitro and In Vivo l Using
Capillary Electrophoresis with Laser-Induced Fluorescence and Liquid
Chromatography with Tandem Mass Spectrometry, Malonne Davies, A. Freed, Sue
Lunte, Kenneth Audus, and J. Cooper.
Characterization of Efflux
Transporters of the Human Trophoblast, Kenneth Audus and Amber Young.
Quantitation of Crystalline and
Amorphous Forms of Anhydrous Neotame Using 13C CPMAS NMR Spectroscopy, T.
James Offerdahl, Jonathon Salsbury, Z. Don-, D.J.W. Grant, and Eric Munson.
Conformational flexibility and
hydrogen-bonding patterns of the neotame molecule in its various solid forms,
Eric Munson, D.J.W. Grant, S.A. Schroeder. Z. Dong, and I. Prakash.
Crystal Structures from Powder
X-Ray Diffractometry: Neotame and Warfarin Sodium 2-Propanol Adduct, V .G.
Young Jr., D.J.W. Grant, Z. Dong, Eric Munson, and A.R. Sheth.
Prediction of Chemical Stability
of Pharmaceutical Compounds and StructureReactivity Relationship, J. Tian and
Valentino Stella.
Kinetics of Asparagine
Deamidation in a & [beta]-Hairpin Peptide, Elizabeth Topp, C.E. Stotz, and
David Vander Velde.
Analysis of 8-Hydroxy-2'-deoxyguanosine in Microdialysis Samples by Capillary
Electrophoresis with Electrochemical Detection, S. Arnett and Craig Lunte.
Painting the Protein Landscape
Creation of a Protein Phase Diagram of Bovine Granulocyte Colony Stimulating
Factor, C. Russell Middaugh, L.A. Kueltzo, and J. Ralston.
Biophysical Characterization of
Peptoid/ Lipitoid:DNA Complexes, C. Russell Middaugh, R. Zuckermann, and Brian
Lobo.
Calorimetric Evaluation of
Protein/ Amino Acid Interactions upon Freezedrying, J. Howard Rytting, S.
Sane, and Fei Tian.
The Interaction of the
Penetration Enhancer DDAIP With a Phospholipid Model Membrane, B.C. Finnin,
B.L. Reed, A. Marie Wolka, and J. Howard Rytting.
The Free Energy/Temperature
Phase Diagram and Apparent Solubility of Eplerenone, Fei Tian, D. Gao, S. Ganser,
Ronald Borchardt and J. Howard Rytting.
Development a new method for
drug formulation for fast release using nearcritical carbon dioxide, Roger
Rajewski, Fenghui Niu, Bala Subramaniam, and John Haslam.
Evaluation of an aqueous formulation of etomidate utilizing sulfobutyl
ether- &[beta] -cyclodextrin as a solubilizing vehicle, Michelle Mclntosh
and Roger Rajewski. •