Abstracts From AAPS Annual Meeting
The following papers were presented at the Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists October 21-25, 2001.
"A Long-term Stability Study of a Novel Phosphate Prodrug of Camptothecin." Bradley A. Hanson and Valentino J. Stella.
"A Perfect Fit: Adaphostin Complexing with SBE7M-b-CD, and HP-b-CD." Leroy A. Chimilio, Valentino Stella, Sugan-thi Chinnaswamy, Muhanned Jumma and Shankar Gupta.
"Effect of Cyclodextrin Charge on Complexation of Neutral and Charged Substrates: Comparison of (SBE)7M-þ-CD to HP-þ-CD." V. Zia, Roger A. Rajewski and Valentino J. Stella.
"Osmotic Properties of Sulfobutylether and Hydro-xypropyl Cyclodextrins." Erika A Zannou, William H. Streng and Valentino J. Stella. "pH-Stability and Degradation Profile of Adaphostin (NSC-680410)." Suganthi Chinnas-wamy, Leroy Chimilio, Valentino J. Stella, Mouhannad Jumaa and Shanker Gupta.
"Plasma Pharmacokinetics of the Lactone and Carboxylate Forms of the POM Prodrug of Camp-tothecin and Camptothecin in Rats." Bradley A. Hanson, Michelle P. McIntosh, David G. Kosednar, Roger A. Rajewski and Valentino J. Stella.
"Preformulation Study of an Anticancer Alkylating Agent with Poor Stability and Solubility Properties; Nanosuspension as a Novel Alternative Formulation." Mouhannad Jumaa, Valentino J. Stella, Leroy Chimilio, Suganthi Chinnaswamy and Shanker Gupta.
"Stability of an Anticancer Alkylating Agent in Different Media; How Can the Solution Components Effect the Degradation Pathway?" Mouhannad Jumaa, Valentino J. Stella, Suganthi Chinnaswamy, Leroy Chimilio and Shanker Gupta.
"Analysis of 8-Hydroxy-deoxyguanosine in Physiological Samples by Capillary Electrophoresis with Electrochemical Detection Using pH-Mediated Sample Stacking." Stacy D. Arnett and Craig E. Lunte.
"Correlation of the Capacity Factor in Vesicular Electrokinetic Chromatography with the Octanol: Water Partition Coefficient for Charged and Neutral Analytes." J.L. Razak, B.J. Cutak, C.K. Larive and Craig E. Lunte.
"Microfabricated Electrophoresis Chip for Simultaneous Bioassays of Nitrite and Nitrate mM with a detection limit of 25 nM." Ruri Kikura-Hanajiri, Robert S. Martin and Susan M. Lunte.
"The Investigation of Epithelial Permeability Using a Cell-Coated Microdialysis Probe." Ziping Yang, Jennifer L. Razak, Sarah F. McDonald and Craig E. Lunte.
"A Functional Assay for Quantitation of the Apparent Affinities of Ligands of P-Glycoprotein in Caco-2 Cells." Jinnian Gao, Osamu Murase, Richard L Schowen, Jeffrey Aube and Ronald T. Borchardt.
"A Modified Coumarinic Acid-based Cyclic Prodrug of an Opioid Peptide: Enzymatic/Chemical Stability and Cellular Transport Characteristics." Hui Ouyang, Fuxing Tang, Dhiren R. Thakker, Teruna J. Siahaan and Ronald T. Borchardt.
"A Novel Model to Describe P-glycoprotein Inhibition Kinetics In Vitro." Erin D. Hugger, Roger A. Poorman, Ferenc J. Kezdy, Thomas J. Raub, Philip S. Burton and Ronald T. Borchardt.
"Are MDCK Cells Transfected with the Human MDR1 Gene a Good Model of the Human Intestinal Mucosa?" Fuxing Tang, Kazutoshi Horie and Ronald T. Borchardt.
"Automated Analysis of Polyethylene Glycol (PEG)-induced Inhibition of P-glycoprotein Activity." Erin D. Hugger, Clayton J. Cole, James S. Bourdage, Thomas J. Raub, Philip S. Burton and Ronald T. Borchardt.
"Characterization of the Efflux Transporter(s) Responsible for Restricting Intestinal Mucosa Permeation of the Acyloxyalkoxy-based Cyclic Prodrug of the Opioid Peptide DADLE." Fuxing Tang and Ronald T. Borchardt.
"Evaluation of the Permeability Characteristics of a Model Opioid Peptide and Its Cyclic Prodrugs Across the Blood-brain Barrier Using an In Situ Perfused Rat Brain Model." Rikke Andersen, Lisbeth H. Nielsen, Weiqing Chen, Jerry Z. Yang and Ronald T. Borchardt.
"In Vitro Stability and In Vivo Pharmacokinetic Studies of A Model Opioid Peptide and Its Cyclic Prodrugs." Jerry Z. Yang, Weiqing Chen and Ronald T. Borchardt.
"Isolation and Characterization of Caco-2 Subclones that Over-express Efflux Transporters." Kazutoshi Horie, Fuxing Tang and Ronald T. Borchardt.
"Structure and Stability of a Type I' Beta-Hairpin Turn." Carol E. Stotz, Ronald T. Borchardt, C. Russell Middaugh, Richard L. Schowen and Elizabeth M. Topp.
"Synthesis of Model Cyclic þ-Turn Peptides and Their Linear Analogs." Stephanie Winslow, Qiang Yu, Teruna Siahaan, Ronald Borchardt and Elizabeth Topp.
"Synthesis of Polyvinylpyrrolidone-Based Polymeric Prodrug." Ajit Joseph M. D'Souza, Richard L. Schowen, Ronald T. Borchardt and Elizabeth M. Topp.
"The Degradation of DL-PLGA and Its Effects on the Deam-idation of an Incorporated Asn-hexapeptide." Mary L. Houchin, Ronald T. Borchardt, Richard L. Schowen and Elizabeth M. Topp.
"The Effect of a Glutamic Acid Residue on the C-terminal Side of an Asparagine Residue on Its Rate of Deamidation." Bei Li, Richard L. Schowen and Ronald T. Borchardt.
"Improving the Selectivity of HAV-Peptides in Modulating E-Cadherin-E-Cadherin Interactions in the Intercellular Junction of MDCK Cell Monolayers." Irwan T Makagiansar, Mike Avery, Yongbo Hu, Kenneth L. Audus and Teruna J Siahaan.
"Photolysis of Glutathione in Aqueous Solution and in Polymeric Films." Yuan Song, Jiangning Ji, Susan Hovorka, John Haslam, Richard L. Schowen, Elizabeth M. Topp and Christian Schneich.
"Evaluation of the DNA Structure in Cationic Lipid and Polymer Complexes." Chad S. Braun and C. Russell Middaugh.
"Formulation and Characterization of Insulin-polyethylenimine-dextran Sulfate Nanoparticles." Waree Tiyaboonchai, James Woiszwillo and C. Russell Middaugh.
"Physical Characterization of Polyethylenimine/DNA Complexes." Sirirat Choosakoon-kriang and C. Russell Middaugh.
"Thermal Stability of Plasmid DNA in Cationic Lipid/DNA Complexes." Brian A. Lobo and C. Russell Middaugh.
Does Treatment with the Enhancer Padimate O or Octyl Salicylate Lead to Skin Delipid-ization?" Anne M. Wolka, Barrie C. Finnin and J. H. Rytting.
"Binding and Internalization of an LFA-1-Derived Cyclic Peptide by ICAM Receptors on Activated Lymphocyte: A Potential Ligand for Drug Targeting to ICAM-1-Expressing Cells." Helena Yusuf-Makagiansar and Teruna J Siahaan.
"Modulation of Paracellular Permeability: Secondary Structure of the HAV and ADT Peptides Derived form Human E-Cadherin Sequence." Christine R. Xu, Ernawati Sinaga and Teruna J. Siahaan.